OBJECTIVE: To conduct an expert-led process for identifying research priorities in adolescent sexual and reproductive health in low- and middle-income countries.METHODS: The authors modified the priority-setting method of the Child Health and Nutrition Research Initiative (CHNRI) to obtain input from nearly 300 researchers, health programme manager
Abstract Background Tumor neoantigen peptide-based vaccines, systemic immunotherapies that enhance antitumor immunity by activating and expanding antigen-specific T cells, have achieved remarkable results in the treatment of a variety of solid tumors.However, how to effectively deliver neoantigens to induce robust antitumor immune responses remains
When the end leakage flux or end leakage inductance cannot be ignored in a permanent magnet (PM) machine (e.g., a PM machine with a short axial length), the analysis of the machine is a time-consuming three-dimensional (3-D) issue.Existing research has made the end leakage inductance no longer to hinder that the performance calculation Tridonic PCI
Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function.The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs).We have LIQUID CRYSTAL previously shown that PDE8A, a PDE isoform with 40-100-fold greater affinity for cAMP than P